On the day following the proclamation of Independence in Equatorial Guinea, in a black neighbourhood of Santa Isabel on the island of Fernando Po, someone finds the body of Pablo Montesinos, one of the ringleaders of the Spanish community in the city. It looks exactly like a natural death, but the Civil Guard officer in charge of completing the relevant paper work begins to follow up leads… From this opening, Casino de Santa Isabel recreates the last days of the Spanish presence in Guinea and the disastrous decolonisation process. A story of irresponsible political decisions, economic interests, discrimination between blacks and whites, men and women… but also of uprooting, exile, truncated love affairs and a lost paradise.